The phosphorylated HER3 supplies docking web sites for p85 subunit of PI3K. The entirely activated PI3K advanced is created by binding of p110 subunit of PI3K to p85 which is able to generate PIP3 through phosphorylating the PIP2. AKT binds to PIP3 and is also phosphorylated by PDK1 and mTORC2. Phos